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ABclonal Technology 488 Rabbit anti-Human CD146
Supplier: ABclonal Technology A22520500T
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily protein originally identified as a cell surface adhesion marker for melanoma progression and metastasis It is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells Increased MCAM expression is found in disorders involving angiogenesis such as inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure MCAM-expressing mesenchymal stromal cells (hMSC) maintain hematopoietic stem and progenitor cell (HSPC) self-renewal through direct contact Activation of the Notch pathway may contribute to HSPC maintenance Additionally MCAM is involved in multiple sclerosis where endothelial MCAM in the blood-brain barrier facilitates lymphocyte transmigration and inflammatory lesion formation
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