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Medchemexpress LLC 5-Aza-4'-thio-2'-deoxycytidine | 169514-76-5 | 99.1% | 244.27 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139015
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. It is a sulfur-containing deoxy-cytidine analog with potential for DNA hypomethylating and antitumor effects.
- Orally active DNA methyltransferase I (DNMT1) inhibitor
- Sulfur-containing deoxy-cytidine analog
- Potential for DNA hypomethylating and antitumor effects
- Inhibits leukemia cell lines and decreases viability in carcinoma lines
- Depletes DNMT1 in various cell types
- Induces CpG demethylation and re-expression of the p15 tumor suppressor gene
- Effective against NCI-H23 tumor xenografts
- Decreases DNMT1 levels in tumors and provides modest suppression of tumor growth in certain xenograft models
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