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Medchemexpress LLC 5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]meth | 1093108-50-9 | 99.4% | 501.50 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1141411MG

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BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). It has IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. This compound shows potential for the treatment of poorly controlled asthma.

  • Highly specific and potent antagonist of DP2/CRTH2
  • Potential for treating poorly controlled asthma
  • Exhibits low nM potency against human or mouse CRTH2 in transfected cells
  • Significantly inhibits AHR in mice
  • Effectively blocks edema formation and reduces inflammatory infiltrate and skin pathology in drug vehicle-treated animals

Catalog No. 50-004-36764


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