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Medchemexpress LLC 8-(3,5-difluoro-2-pyridinyl)-N-[11-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl | 2417371-71-0 | MFCD32689578 | 100.0% | C56H67F2N9O8S2 | 10MG
Supplier: Medchemexpress LLC HY129937A10MG
GNE-987 is a proteolysis targeting chimera (PROTAC) that recruits the VHL E3 ligase to induce targeted degradation of BRD4. It displays picomolar cellular degradation potency and low-nanomolar bromodomain binding, making it suitable for mechanistic studies of BRD4 biology and PROTAC development.
- Induces potent BRD4 degradation at picomolar concentrations
- Binds BD1 and BD2 bromodomains with low-nanomolar affinity
- Applicable for PROTAC-antibody conjugate development
- High reported purity suitable for biochemical studies
- Soluble in DMSO and formulatable for in vivo dosing
- Recommended storage under inert atmosphere at low temperatures
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