Medchemexpress LLC 2-Pyrimidinamine, 4-[4-(1H-imidazol-1-yl)phenyl]-N-2-propyn-1-yl- | 2234272-10-5 | 98.1% | 50 MG

Supplier:  Medchemexpress LLC HY13053050MG

AP-C5 is a selective inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2. It is used for the research of diarrheal disease. This compound is also a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.

• Potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation
• Effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue
• Potentiates cAMP signaling through PDE inhibition
• Partially blocks heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum
• Click chemistry reagent with an alkyne group
• Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)

Catalog No. 50-003-40340