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Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG
Supplier: Medchemexpress LLC HY111388A10MM/1ML
Romaciclib monohydrochloride (SEL120-34A monohydrochloride) is an ATP-competitive and selective inhibitor of Cyclin-Dependent Kinase 8 (CDK8). It demonstrates potent inhibitory activity against the kinase complexes of CDK8/CycC and CDK19/CycC, with IC50 values of 4.4 nM and 10.4 nM, respectively, and a Kd of 3 nM for CDK8. While it weakly inhibits CDK9, it shows no significant activity against other CDKs such as CDK1, 2, 4, 6, 5, and 7. The compound effectively inhibits the phosphorylation of STAT1 S727 and STAT5 S726 and has demonstrated anti-tumor activity.
- Selective inhibition of specific cyclin-dependent kinases.
- ATP-competitive mechanism of action.
- Impacts key signaling pathways by inhibiting STAT1 S727 and STAT5 S726 phosphorylation.
- Demonstrated efficacy in anti-tumor applications.
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