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Medchemexpress LLC Nilotinib | 641571-10-0 | 99.9% | 529.52 | 200 MG
Supplier: Medchemexpress LLC 200MGHY10159
Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity, designed for research use. It exhibits significant inhibitory effects against Bcr-Abl and various other targets, making it suitable for studies on cell proliferation and cytotoxicity.
- Exhibits antiproliferative activity in A549 cells with an IC50 of 6.63 μM.
- Shows antiproliferative activity in BJ cells with an IC50 of 12.8 μM.
- Inhibits various BCR/ABL p210 mutants (GI50 0.004 μM to > 10 μM).
- Induces cytotoxicity against various BaF3 cell lines.
- Used in CCK-8 assays for IC50 assessment in liver cancer cell lines.
- Useful for observing anti-colony formation effects.
- Utilized for immunohistochemistry of primary tumors.
- Investigated for its direct effect on cytotoxic lymphocytes.
- Applied for cell cycle analysis.
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