Medchemexpress LLC 5Z-7-Oxozeaenol | 253863-19-3 | 99.3% | 10 MG

Supplier:  Medchemexpress LLC HY1268610MG

5Z-7-Oxozeaenol is a natural anti-protozoan compound of fungal origin, serving as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2, with IC50 values of 8 nM and 52 nM, respectively.

• Potent, irreversible, and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC50: 8.1 nM).
• Less active on MEK1 (IC50: 411 nM).
• Prevents inflammation by inhibiting TAK1 MAPK kinase kinase catalytic activity.
• Inhibitor of VEGF-R2 (IC50: 52 nM).
• Also inhibits VEGF-R3 (IC50: 110 nM), FLT3 (IC50: 170 nM), PDGFR-β (IC50: 340 nM), B-RAF VE (IC50: 6300 nM), and SRC (IC50: 6600 nM).
• Inhibits JNK/p38 pathway (signal-specific, not a direct inhibitor).
• Suppresses PMA-induced AP-1 activity in KT cells; no effect on IL-1-induced NF-kB activity in KK cells.

Catalog No. 50-003-40828