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Medchemexpress LLC 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile | 1628208-23-0 | 98.2% | 278.31 | C16H14N4O | 100 MG
SDP

Supplier:  Medchemexpress LLC HY100421100MG

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CPI-455 is a selective, cell-active inhibitor of the KDM5 (lysine demethylase 5) family. It increases global H3K4 trimethylation, shows potent biochemical inhibition of KDM5A (reported IC50 ≈ 10 nM), and reduces the number of drug-tolerant persister cancer cells in cell-based models. CPI-455 is used as a research tool to probe KDM5 biology and epigenetic regulation in cancer and other systems.

  • Potent enzyme inhibition with reported low-nanomolar activity.
  • Cell-active modulation of histone H3K4 trimethylation.
  • Useful for studying drug-tolerant persister phenotypes in cancer models.
  • High reported purity suitable for biochemical and cellular assays.
  • Stable powdered compound for standard cold storage and handling.

Catalog No. 50-002-14794


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