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ABclonal Technology 647 anti-Human CD120b/TNFRSF1B
Supplier: ABclonal Technology A23222500T
The protein encoded by this gene is a member of the TNF-receptor superfamily This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins c-IAP1 and c-IAP2 which possess E3 ubiquitin ligase activity The function of IAPs in TNF-receptor signalling is unknown however c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 which mediates anti-apoptotic signals Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways
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