ABclonal Technology 647 Rabbit anti-Human CD40

Supplier:  ABclonal Technology A22642100T

This gene belongs to the TNF-receptor superfamily and encodes a receptor on immune system antigen-presenting cells It mediates various immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation AKNA transcription factor regulates the receptor and its ligand important for homotypic cell interactions The adaptor protein TNFR2 mediates signal transduction The receptor-ligand interaction is essential for amyloid-beta-induced microglial activation potentially playing a role in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported

Catalog No. 50-000-07714