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Cayman Chemical 7 S 17 Sdihydroxy8 E 10 Z 13
Supplier: Cayman Chemical 1054625 UG
A specialized pro-resolving mediator; induces activation of GPR101, GPR32, and GPR18 in β-arrestin recruitment assays using CHO cells expressing the human receptors (EC50s = 4.6, 14, and 1.5 pM, respectively); increases efferocytosis of apoptotic HL-60 cells and phagocytosis of S. aureus bioparticles by isolated human monocyte-derived macrophages at 1 nM; prevents weight loss and decreases disease severity and hind paw edema in a K/BxN serum transfer-induced mouse model of inflammatory arthritis at 150 ng/animal; decreases blood leukocyte activation and aortic lesions in ApoE-/- mice fed a western diet; plasma levels are increased in patients with PDAC
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