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Medchemexpress LLC 8-Shogaol | 36700-45-5 | 1 ML
SDP

Supplier:  Medchemexpress LLC HYN243510MM/1ML

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8-Shogaol, a stimulating compound from ginger, exhibits antiplatelet, anti-cancer, and anti-inflammatory activities. It inhibits COX-2, leading to a decline in human leukemia cells, and selectively targets TAK1, suppressing IKK, Akt, and MAPK signaling pathways. It also reverses synovitis in rheumatoid arthritis (RA) and demonstrates cytotoxic effects on HL-60 cell growth and inhibits inflammation in RA patient-derived FLS.

  • Exhibits antiplatelet, anti-cancer, and anti-inflammatory activities.
  • Inhibits COX-2 (IC50=17.5 μM) and selectively targets TAK1 (IC50=5 μM).
  • Suppresses IKK, Akt, and MAPK signaling pathways.
  • Reverses synovitis in rheumatoid arthritis.
  • Cytotoxic to HL-60 cell growth (10-50 μM).
  • Inhibits TNF-α, IL-1β, and IL-17-mediated inflammation.
  • Reduces paw thickness and improves walking performance in rat models of adjuvant-induced arthritis.

Catalog No. 50-004-21850


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