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Medchemexpress LLC A-395 hydrochloride | 2089148-72-9 | MFCD31563589 | 98.4% | 486.65 g·mol⁻1 | C26H35FN4O2S · xHCl | 1 ML
SDP

Supplier:  Medchemexpress LLC HY10151210MM 1ML

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A-395 hydrochloride is a small-molecule chemical probe that antagonizes the EED subunit of the Polycomb repressive complex 2 (PRC2). It binds in the H3K27me3-binding pocket of EED, preventing allosteric activation of EZH2 and reducing H3K27 methylation; it shows potent inhibition of the PRC2 complex (reported IC50 ≈ 18 nM). The compound is supplied as the hydrochloride salt and is commonly used in biochemical and cellular studies.

  • Potent EED antagonist with low-nanomolar PRC2 inhibition.
  • Prevents allosteric activation of EZH2 and reduces H3K27 methylation.
  • Validated in structural and biochemical studies for target engagement.
  • Suitable as a chemical probe for studying PRC2 biology in cells and assays.
  • Supplied as a hydrochloride salt with good solubility in DMSO.
  • Available in solution formats for direct use in biochemical assays.

Catalog No. 50-002-48411


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