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Cayman Chemical A-395hydrochlorIde 10mg
Supplier: Cayman Chemical 2025710 MG
An EED protein-protein interaction inhibitor; binds to the EED subunit of PRC2 and inhibits H3K27 methylation (Ki = 0.4 nM); inhibits H3K27 di- and trimethylation in RD rhabdoid tumor cells (IC50s = 390 and 90 nM, respectively); reduces tumor volume and intratumor H3K27 trimethylation in a Pfeiffer DLBCL mouse xenograft model at 200 mg/kg
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