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Bachem Amyloid Beta Protein (4-42) Ammonium
Supplier: Bachem 4090138.0500
Amyloid Beta Protein (4-42) Ammonium, H-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH, 157884-72-5, C191H294N52O53S, Mr 4198.82, 0.5mg. Ab (4-42). Ab 4-42 could be one of the earliest and most prominent Ab species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Ab had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Ab 4-42 as a major Ab species in AD patients. Additionally, Ab 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Ab 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Ab 4-42 may contribute to the development of multiple CNS diseases.
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