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Apexbio Technology LLC A-443654 552325-16-3 5mg
Supplier: Apexbio Technology LLC A31355
A-443654 (CAS 552325-16-3) is a potent selective small molecule inhibitor targeting all three Akt isoforms by binding the ATP pocket and reversibly inhibiting kinase activity (Ki 160 pM) It shows strong selectivity for Akt over other kinases and suppresses downstream substrate phosphorylation including GSK3 FOXO3 TSC2 mTOR 4EBP-1 and S6 In cellular assays A-443654 inhibits Akt activity and induces apoptosis or cell cycle arrest across cancer models with reported EC50 values of 100 nM (MiaPaCa-2) and 0 63 M (CLL cells) In in vivo xenograft models it significantly reduces tumor growth either as monotherapy or in combination with rapamycin A-443654 is widely applied in studies of PI3K/Akt signaling cancer progression and therapeutic response
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