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AdipoGen A-443654 (5 mg)
SDP

Supplier:  AdipoGen AGCR13663M005

Encompass_Preferred

Chemical. CAS: 552325-16-3. Formula: C24H23N5O. MW: 397.5. Synthetic. Potent and selective Akt inhibitor (Ki=160pmol/L for all three isoforms PKBalpha, PKBbeta and PKBgamma). DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1 and DYRK3 at low nM range as well. Interferes with mitotic progression by regulating aurora a kinase expression and bipolar spindle formation. It induces G2/M accumulation, defects in centrosome separation and formation of either monopolar arrays or disorganized spindles. Anticancer agent. Apoptosis inducer and chemosensitizing agent. Slows the progression and growth of Akt-dependent tumors. Induces rapid Akt Ser473 phosphorylation independent of mTORC1 inhibition in human cancer cell lines. Activates mTORC2 and reverses long-term memory deficits.

Catalog No. 50-205-4044


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