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Apexbio Technology LLC A-54556A(Synonyms: A54556A, Antibiotic A54556A, Acyl depsipeptide antibiotic, ADEP, Natural acyldepsipeptide antibiotic), 1mg, CAS: 95398-45-1.
Supplier: Apexbio Technology LLC C31731
A-54556A (CAS 95398-45-1) is a naturally occurring antibiotic belonging to the acyldepsipeptide (ADEP) class It exerts antibacterial effects against Gram-positive bacteria through activation and dysregulation of the bacterial caseinolytic protease ClpP a mechanism distinct from conventional antibiotics Against Bacillus subtilis 168 it demonstrates an IC50 of 0 2 g/ml and at concentrations from 0 4 mg/ml it induces filamentation and bacterial cell death without immediate inhibition of DNA RNA or protein synthesis Currently in preclinical investigation A-54556A has important potential as a tool for antimicrobial resistance studies and novel antibiotic development
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