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Medchemexpress LLC A 779 | 159432-28-7 | 99.3% | 872.97 | 50 MG
Supplier: Medchemexpress LLC HYP021650MG
A 779 is a specific antagonist of the G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII. It is intended for research use only.
- Specific antagonist of the G-protein coupled Mas receptor
- Inhibits the effect of Ang-(1-7)
- Suppresses PCNA protein expression upregulated by Ang II
- Retards Ang II-induced inflammatory responses in VSMCs
- Blocks Ang-(1-7) effect on Akt and ERK1/2 phosphorylation
- Elevates several serum bone markers (BALP, CTX, TRAcP 5b, OC, DPD)
- Abolishes Ang(1-7) favorable effects on bone health
- Eradicates captopril's protective effects on bone metabolism
- Restores OVX effects on RANKL expression and the ACE-1/AngII/AT1R cascade
- Down-regulates OPG expression and the ACE-2/Ang1-7/Mas pathway
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