ABclonal Technology [KO Validated] PRKAR1A Rabbit pAb

Supplier:  ABclonal Technology A0906500UL

cAMP is a signaling molecule that activates cAMP-dependent protein kinase, which transduces signals through phosphorylation of target proteins. The inactive kinase is a tetramer of two regulatory and two catalytic subunits. cAMP dissociates this holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free catalytic subunits. This gene encodes one of the regulatory subunits and was found to down-regulate liver gene expression in hepatoma-fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). The gene can fuse with the RET protooncogene to form the PTC2 chimeric oncogene in thyroid tumors. A nonconventional nuclear localization sequence suggests its role in DNA replication by transporting the RFC40 subunit. Several splice variants encoding different isoforms have been observed.

Catalog No. 50-001-38662