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ABclonal Technology Ran Rabbit pAb
Supplier: ABclonal Technology A0976500UL
RAN (ras-related nuclear protein) is a small GTP-binding protein in the RAS superfamily, essential for RNA and protein translocation through the nuclear pore complex. It also regulates DNA synthesis and cell cycle progression. RANs nuclear localization requires regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Besides its role in nuclear-cytosol exchange, RAN also influences microtubule network formation and organization, particularly during mitosis. RCC1 generates a high concentration of RAN-GTP near chromatin, promoting microtubule nucleation. RAN is an androgen receptor (AR) coactivator and interacts differently with polyglutamine in AR. Expansion of polyglutamine repeats in AR is linked to Kennedys disease (spinal and bulbar muscular atrophy), where weak coactivation may lead to partial androgen insensitivity.
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