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Cayman Chemical A2AR AgonIst-1 5mg
Supplier: Cayman Chemical 284145 MG
An agonist of the adenosine A2A receptor and an inhibitor of ENT1 (Kis = 4.39 and 3.47 µM, for the human receptor and guinea pig transporter, respectively); decreases adenosine uptake by 80% in PC12 cells at 61 µM and increases brain levels of adenosine in a transgenic mouse model of Huntington’s disease at 20 mg/kg; rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease at 0.11 mg/kg
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