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ABclonal Technology Pan DiMethyl-lysine Rabbit pAb
Supplier: ABclonal Technology A58701000UL
Methylation is a key post-translational modification (PTM) by methyltransferases, playing a crucial role in gene expression, protein activity, stability, and signal transduction. It occurs on lysine or arginine residues in both histone and nonhistone proteins, affecting protein properties. Lysine can be mono-, di-, or trimethylated, reflecting its functional diversity. For example, Lys9 of histone H3 is methylated by G9A/GLP (mono/di) and SETDB1 (tri) to activate transcription. The tumor suppressor p53 is regulated by methylation at several sites: mono-methylation at Lys370 by SMYD2 represses transcription, while di-methylation at the same site prevents p53-53BP1 interaction. Di-methylation at Lys382 inhibits p53 ubiquitination after DNA damage, and di-methylation at Lys373 by G9A/GLP impairs p53-mediated apoptosis, correlating with tri-methylation of histone H3 Lys9 at the p21 promoter.
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