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Medchemexpress LLC A6770 | 1331754-16-5 | ≥99.0% | 140.14 | 1 MG
Supplier: Medchemexpress LLC HY1390941MG
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. It directly inhibits S1P lyase when phosphorylated. A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase and leads to S1PL inhibition. In vivo, A6770 reduces peripheral lymphocyte numbers in rats.
- Increases [3H]dhS1P in a concentration-dependent manner
- Causes S1PL inhibition
- Reduces peripheral lymphocyte numbers in rats
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