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ABclonal Technology ABflo 488 Rabbit anti-Dog CD4
Supplier: ABclonal Technology A22687500T
This integral membrane glycoprotein is crucial in the immune response functioning in both external and internal defense mechanisms In T-cells it acts as a coreceptor for MHC class II molecules interacting with the T-cell receptor (TCR) and MHC class II on antigen-presenting cells (APCs) This interaction recruits the Src kinase LCK initiating intracellular signaling that leads to lymphokine production motility adhesion and activation of T-helper cells In macrophages and NK cells it supports differentiation cytokine expression and migration through a TCR LCK-independent pathway Additionally it aids in the development of T-helper cells in the thymus and the differentiation of monocytes into mature macrophages
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