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Cayman Chemical ABOhydrochlorIde 10mg
Supplier: Cayman Chemical 2151510 MG
A modulator of annexin A7; binds to Thr286 and inhibits phosphorylation of annexin A7 at threonine residues in HUVECs; enhances the interaction between annexin A7 and GCA, decreases GCA phosphorylation as well as intracellular calcium concentration, and promotes autophagy in COS-7 cells; decreases phosphorylation of LC3; suppresses oxidized low-density lipoprotein-induced increases in PC-PLC expression in VECs; decreases PC-PLC levels, enhances autophagy, and reduces apoptosis, lipid deposition, and atherosclerotic plaque area in the aortic endothelium of apoE-/- mice fed a Western diet at 50 or 100 mg/kg per day
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