Apexbio Technology LLC AC 55541 916170-19-9 5mg

Supplier:  Apexbio Technology LLC A86695

AC 55541 (CAS 916170-19-9) is a potent and selective agonist of protease-activated receptor 2 (PAR2) exhibiting a pEC50 of 6 7 with activity in the 200 1000 nM range PAR2 a member of the seven-transmembrane G protein-coupled receptor family is implicated in modulating inflammatory responses AC 55541 selectively activates PAR2 without affecting PAR1 in NIH-3T3 cell proliferation assays it stimulates cell growth via PAR2 activation Cells expressing the PAR2 F240S constitutively active mutant display heightened sensitivity to AC 55541 compared to peptide agonists In human corneal epithelial cells AC 55541 induces PAR2 expression and modulates inflammatory signaling In vivo local administration of AC 55541 provokes dose-dependent edema and thermal hyperalgesia in rodent models supporting its utility in pain and inflammation research

Catalog No. 50-000-95926