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Apexbio Technology LLC Acalisib (GS-9820) 870281-34-8 5mg
Supplier: Apexbio Technology LLC B58315
Acalisib (GS-9820 CAS 870281-34-8) is a potent and selective inhibitor of phosphoinositide 3-kinase delta (PI3K ) exhibiting an IC50 of 12 7 nM for this isoform PI3K predominantly expressed in hematopoietic cells is involved in modulating inflammatory responses immune cell function migration and vesicular trafficking Acalisib demonstrates high selectivity with much higher IC50 values for PI3K (5441 nM) PI3K (3377 nM) and PI3K (1389 nM) In cellular assays acalisib inhibits PI3K -mediated processes such as Fc RI-stimulated CD63 expression in basophils (EC50 14 nM) and affects osteoclast cytoskeletal organization and survival This compound is valuable for investigating PI3K signaling in immune and bone biology research
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