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Cayman Chemical Aceclofenac 25g
SDP

Supplier:  Cayman Chemical 2862025 G

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An NSAID; selectively inhibits human COX-2 (IC50 = 0.8 μM) over COX-1 (IC50 = >100 μM) in isolated whole blood; inhibits PGE2 production in patient-derived human rheumatoid synovial cells (IC50s = 1.9-29.4 nM); reduces IL-1β-induced increases in IL-6 production by 21 and 43% in cultured chondrocytes without and with osteoarthritic lesions, respectively, at 30 μM; inhibits carrageenan-induced paw edema (ED50 = 3.6 mg/kg) and abscess formation (ED30 = 1.1 mg/kg) in rats; inhibits an increase in joint diameter in a rat model of CFA-induced arthritis

Catalog No. 50-293-7916


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