Medchemexpress LLC Acetamide, 2-[[2-(5-bromo-2-furanyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]- | 819827-50-4 | 98.0% | 364.15 | 10 MG

Supplier:  Medchemexpress LLC HY11145010MM/1ML

CB7993113 is a potent AHR antagonist that directly binds AHR protein and blocks AHR nuclear translocation, inhibiting PAH- and TCDD-induced reporter activity. It shows no toxicity in various human cells and effectively reduces the invasive phenotype of breast cancer cells in vitro.

• Potent AHR antagonist with an IC50 of 0.33 μM.
• Directly binds AHR protein.
• Blocks AHR nuclear translocation.
• Inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively.
• Exhibits no toxicity in several human cell types up to 20 μM.
• Significantly reduces the invasive phenotype of breast cancer cells in vitro.
• Effectively blocks acute, 50 mg/kg DMBA-induced hepatic CYP1A1 induction and bone marrow toxicity in vivo.

Catalog No. 50-003-45718