Medchemexpress LLC Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- | 518303-20-3 | MFCD03471890 | 99.7% | 468.34 | 100 MG

Supplier:  Medchemexpress LLC HY18628100MG

UMI-77 is a selective Mcl-1 inhibitor, demonstrating high binding affinity to Mcl-1 (IC50=0.31 μM). It binds to the BH3 binding groove of Mcl-1 with a Ki of 490 nM, showcasing selectivity over other anti-apoptotic Bcl-2 family members.

• Selective Mcl-1 inhibitor.
• High binding affinity to Mcl-1 (IC50=0.31 μM).
• Binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM.
• Exhibits selectivity over other members of anti-apoptotic Bcl-2 family.
• Moderate metabolic stability with a half-life of 45 minutes.
• Demonstrates statistically significant tumor growth inhibition in vivo.

Catalog No. 50-003-88008