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Medchemexpress LLC Acoltremon | 68489-09-8 | 99.1% | 289.41 | 50 MG
Supplier: Medchemexpress LLC HY108449500MG
Acoltremon is a potent and selective TRPM8 agonist, which is a menthol derivative that acts as a cooling agent. This compound demonstrates an analgesic effect and can be utilized in chronic neuropathic pain research.
- Acts as a potent and selective TRPM8 agonist.
- Functions as a cooling agent.
- Shows analgesic effect.
- Can be used in chronic neuropathic pain research.
- Displays TRPM8 agonism in tests on heterologously expressed TRP ion channels in vitro.
- Exhibits highly potent and specific TRPM8 channel agonist activity in DRG neurons in vitro.
- Activates mouse TRPM8 but does not activate or inhibit mouse TRPA1 in HEK293T cells.
- Produces an obvious analgesic effect in mice via selective TRPM8 activation.
- Reduces capsaicin-induced nocifensive behavior in mice.
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