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Medchemexpress LLC Adapalene | 106685-40-9 | 99.9% | C28H28O3 | 100 MG
Supplier: Medchemexpress LLC HYB0091100MG
Adapalene is a third-generation synthetic retinoid widely used for acne research. It acts as a potent RAR agonist, with AC50s of 2.3 nM for RARβ, 9.3 nM for RARγ, and 22 nM for RARα. This compound also non-competitively inhibits the enzymatic activity of GOT1 and exhibits anti-tumor activity.
- Third-generation synthetic retinoid
- Potent RAR agonist for RARβ, RARγ, and RARα
- Non-competitive inhibitor of GOT1 enzymatic activity
- Exhibits anti-tumor activity
- Induces apoptosis and inhibits proliferation in ES-2 cells
- Inhibits growth of DLD1 cell-derived xenograft tumors
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