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Apexbio Technology LLC AEG 3482 63735-71-7 10mg
Supplier: Apexbio Technology LLC B901010
AEG 3482 (CAS 63735-71-7) is a small molecule inhibitor that impedes Jun N-terminal kinase (JNK)-dependent apoptotic signaling By interfering with the JNK pathway which is implicated in neuronal cell death and activated in models of Alzheimer s and Huntington s disease AEG 3482 blocks apoptosis induced by p75 neurotrophin receptor (p75NTR) or its adaptor NRAGE The compound promotes expression of heat shock protein 70 (HSP70) an endogenous JNK inhibitor and requires HSP70 accumulation for its anti-apoptotic effect AEG 3482 is used as a research tool for studying neuronal apoptosis and has potential in investigating neuroprotection strategies
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