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Medchemexpress LLC AFM-30a (hydrochloride) | 99.8% | 502.97 | 25 MG
Supplier: Medchemexpress LLC 25MGHY125099A
AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. It binds to PAD2 with an EC50 value of 9.5 μM and inhibits H3 citrullination with an EC50 value of 0.4 μM. It can be used for the research of certain cancers and various autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
- Potent protein arginine deiminase 2 (PAD2) inhibitor
- Excellent PAD2-selectivity
- Inhibits H3 citrullination
- Low cytotoxicity for cells
- Suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice
- For research use only
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