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Cayman Chemical AfuresertIbhydrochlorIde 10mg
Supplier: Cayman Chemical 1798810 MG
A pan-Akt inhibitor (IC50s = 0.08, 2, and 2.6 nM for Akt1, -2, and -3, respectively); selective for Akt over a panel of 13 kinases (IC50s = >100 nM) but does inhibit PKA, PKG1α, and PKG1β (IC50s = 1.3, 0.9, and 4 nM, respectively); inhibits tumor growth in an SKOV3 mouse xenograft model at 10, 30, and 100 mg/kg
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