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Medchemexpress LLC AG-270 | 2201056-66-6 | 99.97% | 489.57 | 50 MG
Supplier: Medchemexpress LLC HY13863050MG
AG-270 is a first-in-class, allosteric, noncompetitive, reversible, and orally active MAT2A inhibitor with an IC50 of 14 nM. It potently reduces intracellular S-adenosylmethionine (SAM) levels and demonstrates MTAP-null-selective antiproliferative activity. In vivo, AG-270 exhibits excellent metabolic stability and leads to dose-dependent reductions in tumor SAM levels and tumor growth in xenografts. Its combination with taxanes and gemcitabine has shown additive-to-synergistic antitumor activity.
- Potent and selective MAT2A inhibitor
- Reduces intracellular SAM levels
- Shows MTAP-null-selective antiproliferative activity
- Excellent metabolic stability across multiple species
- Exhibits dose-dependent reduction in tumor SAM levels and tumor growth
- Additive-to-synergistic antitumor activity in combination with other therapies
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