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Medchemexpress LLC Agi-41998 | 2377492-26-5 | 99.9% | C22H16BrF3N4O2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY145778100MG

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AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. It exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM), and can significantly inhibit the proliferation of HCT-116 cells and tumor growth.

  • Potent and orally active MAT2A inhibitor
  • Effectively penetrates the blood-brain barrier
  • Exhibits inhibitory activities against MAT2A and SAM in HCT-116 MTAP-null cells (IC50s of 22 nM and 34 nM)
  • Can significantly inhibit the proliferation of HCT-116 cells and tumor growth
  • Can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer

Catalog No. 50-003-56246


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