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Apexbio Technology LLC AICAR phosphate 681006-28-0 200mg
SDP

Supplier:  Apexbio Technology LLC B1211200

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AICAR phosphate (CAS 681006-28-0) also known as Acadesine is an activator of AMP-activated protein kinase (AMPK) In studies involving B-cell chronic lymphocytic leukemia (B-CLL) cells AICAR phosphate induces apoptosis in a dose-dependent manner with an EC50 of approximately 380 60 M This apoptotic effect is associated with caspase activation and mitochondrial cytochrome c release Notably AICAR phosphate at concentrations of 2 4 mM has minimal impact on T lymphocyte viability from B-CLL patients indicating selective activity These properties make it a valuable tool for research on AMPK signaling and B-cell malignancy mechanisms

Catalog No. 50-000-90439


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