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Apexbio Technology LLC AIM-100 873305-35-2 100mg
Supplier: Apexbio Technology LLC A3148100
AIM-100 (CAS 873305-35-2) is a potent selective small molecule inhibitor of the Ack1 tyrosine kinase with an IC50 of 24 nM AIM-100 acts as an ATP mimetic significantly suppressing Ack1 activity while exhibiting minimal to no inhibitory effects against a panel of 30 other kinases including PI3-kinase AKT and displaying substantially reduced potency toward Lck In vitro AIM-100 decreases Ack1 activity following EGF stimulation in MEF cells and induces G0/G1 cell cycle arrest and growth inhibition in human prostate and pancreatic cancer cell lines At 10 M it promotes apoptosis in Panc-1 cells and its growth inhibition (GI50) in several cancer cell lines ranges from 7 to 8 M AIM-100 is thus a valuable tool for exploring Ack1-mediated signaling in oncogenic contexts
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