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Cayman Chemical Ala1 3 11 15-EndothelIn-1 5mg
Supplier: Cayman Chemical 390175 MG
An ETB receptor agonist; selectively binds to ETB over ETA receptors (IC50s = 0.33 and 570 nM, respectively, for the porcine receptors); increases wound closure percentage in a scratch assay using HUVECs at 10 or 100 nM; increases body temperature in conscious rabbits at 0.15 or 0.3 nmol/kg; induces bronchoconstriction and increases mean arterial blood pressure in anesthetized guinea pigs at 20 nmol/kg, i.v.; has been used to determine the cross reactivity of monoclonal antibodies against endothelin in enzyme immunometric assays
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