Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Alectinib Hydrochloride 1256589-74-8 50mg
Supplier: Apexbio Technology LLC A464950
Alectinib Hydrochloride (CAS 1256589-74-8) is an orally administered selective inhibitor of anaplastic lymphoma kinase (ALK) that acts by competitively binding to the ATP-binding site of the ALK kinase domain thereby disrupting downstream signaling pathways In vitro studies demonstrate potent inhibition of ALK with an IC50 of approximately 1 9 nM and it also effectively targets ALK mutant variants F1174L (IC50 1 nM) and R1275Q (IC50 3 5 nM) Owing to its ability to penetrate the central nervous system alectinib hydrochloride is utilized in cancer research to investigate ALK-dependent tumorigenesis and mechanisms of drug resistance
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?