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Medchemexpress LLC Alendronate sodium hydrate | 121268-17-5 | 99.6% | 325.12 | 1 ML
Supplier: Medchemexpress LLC HY1110110MM/1ML
Alendronate sodium hydrate is a farnesyl diphosphate synthase inhibitor with an IC50 of 460 nM. It directly acts on osteoclasts, inhibiting a rate-limiting step in the cholesterol biosynthesis pathway, which is crucial for osteoclast function. It inhibits the isoprenoid biosynthesis pathway and interferes with protein prenylation by reducing geranylgeranyl diphosphate levels. Alendronate can cause erosions in the rabbit stomach but not antral ulceration in rats.
- Solid appearance, white to off-white color
- Chemical formula: C4H18NNaO10P2
- Soluble in H2O: ≥ 28.57 mg/mL (87.88 mM)
- Shipping at room temperature in continental US; may vary elsewhere
- Storage at 4°C, sealed, away from moisture
- In solvent storage at -80°C for 6 months or -20°C for 1 month (sealed, away from moisture)
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