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Apexbio Technology LLC Alisol B 23-acetate 26575-95-1 20mg
Supplier: Apexbio Technology LLC N155020
Alisol B 23-acetate (CAS 26575-95-1) is a small molecule farnesoid X receptor (FXR) agonist FXR a nuclear receptor regulating transcriptional responses to bile acids is implicated in hepatocyte proliferation and liver regeneration In cellular assays using HepG2 cells cotransfected with FXR and a bile salt export pump (BSEP) reporter construct Alisol B 23-acetate increased FXR-mediated transcription in a dose-dependent manner with maximal (4 3-fold) induction at 10 M In murine models of partial hepatectomy oral administration of Alisol B 23-acetate enhanced liver regrowth DNA synthesis and mitotic index This compound serves as a valuable tool for investigating FXR signaling in liver regeneration research
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