Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Alvelestat 848141-11-7 100mg
Supplier: Apexbio Technology LLC B1037100
Alvelestat (CAS 848141-11-7) is an orally bioavailable reversible inhibitor of neutrophil elastase (NE) It demonstrates high affinity for human NE exhibiting a Ki of 9 4 nM and over 600-fold selectivity compared to other serine proteases In whole blood cell-based and degranulation assays alvelestat shows pIC50 values of 7 36 7 32 and 7 3 respectively Preclinical studies indicate that alvelestat reduces NE-induced markers of lung injury such as hemoglobin and hydroxyproline levels and attenuates neutrophilic inflammation in models of acute lung injury as well as smoke-induced airway inflammation and emphysema These properties support its use in research on neutrophil-driven pulmonary diseases
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?