Sigma Aldrich Fine Chemicals Biosciences Alzheimers In A DishTM APP

Supplier:  Sigma Aldrich Fine Chemicals Biosciences SCR526

Amyloid-beta plagues and neurofibrillary tangles are key pathological features observed in the brains of Alzheimers patients. Familial early onset forms of AD (FAD) are caused by autosomal dominant inherited genetic mutations and offer an opportunity to study the effects of key mutations on the diseases progression and pathology. To date approximately 200 FAD mutations in APP and/or PSEN1 have been reported. Transgenic mouse models and human neurons harboring FAD mutations in PSEN-1 and/or APP are widely used as model systems and have provide important insights into the disease. Transgenic mouse models are able to recapitulate the loss in cognitive functions along with increased deposition of b-amyloid plagues but are unable to demonstrate neurofibrillary tangles one of the key pathological hallmarks of AD. Similarly human iPSC-derived neurons from FAD patients demonstrated increased levels of the pathogenic AB species and phosphorylated tau but lack the characteristic amyloid-bet

Catalog No. 50-290-7345