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Medchemexpress LLC AM-5308 | 2410796-89-1 | 99.15% | C26H35N5O5S | 100 MG
SDP

Supplier:  Medchemexpress LLC HY144894100MG

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AM-5308 is an inhibitor for KIF18A (IC50=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. It activates mitotic checkpoints, regulates cell division processes including chromosome segregation and spindle assembly, and exhibits antitumor activity.

  • Activates mitotic checkpoints
  • Regulates cell division processes
  • Exhibits antitumor activity
  • Inhibits KIF18A motor (IC50: 0.047 μM)
  • Shows cytotoxicity in human bone marrow cells
  • Arrests cell cycle at mitosis phase (EC50 for MDA-MB-157 is 0.041 μM)
  • Inhibits tumor growth in mouse OVCAR-3 xenograft models

Catalog No. 50-003-53987


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