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Apexbio Technology LLC AMD-070 558447-26-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A31735.1
AMD-070 (CAS 558447-26-0) is a small-molecule antagonist targeting the chemokine receptor CXCR4 It is designed to inhibit CXCR4-mediated signaling thereby regulating cellular migration and CXCL12-induced MAPK pathway activation AMD-070 exerts its biological activity as an allosteric inhibitor of CXCR4 In cell-based studies AMD-070 demonstrates inhibition of tumor cell migration in melanoma cell models and suppresses X4-tropic HIV-1 replication by disrupting the gp120/CXCR4 interaction The compound exhibits an IC50 value of approximately 13 nM for CXCR4 and inhibits HIV-1 replication with IC50 values of 10 nM in human CXCR4-expressing HOS cells and 12 nM in CD4 CXCR4 T cells Based on these pharmacological properties AMD-070 holds research potential in cancer metastasis and HIV infection
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