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Cayman Chemical Ametantrone 10mg

Supplier: Cayman Chemical 2292410 MG
An inhibitor of topoisomerase II; induces double-strand breaks in SV40 DNA in the presence, but not absence, of topoisomerase II and induces single-strand breaks in DNA in NCI H187 cells; induces interstrand DNA cross-links in HeLa S3 cells at a minimum concentration of 4.1 µM; cytotoxic to NCI H187 and HL-60 cells (IC50s = 112 and 0.44 µM, respectively); inhibits tumor growth in a Ridgway osteogenic sarcoma mouse model at 5 mg/kg; increases tumor growth in mouse models of mammary adenocarcinoma and colon adenocarcinoma 11a
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